The never ending chase between the Road Runner and Wile E. Coyote has been used in commercials over the years by a number of different companies. Matthew posted one of the ads for Plymouth last month. Here is a showcase of some other Road Runner related advertisements.
From 1981, Wile E. tries to catch the Road Runner, who is driving a Volkswagen Beetle:
From 1986, the duo play a major role in a bizarre advertisement for Hershey's chocolate... (How '80s can you get??):
Finally (for now, anyway), a priceless promo made for Cartoon Network (back when they were actually worth watching):